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M94A2378.TXT
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1994-10-25
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Document 2378
DOCN M94A2378
TI Determinants of HIV disease progression among homosexual men in the
tricontinental seroconverter study.
DT 9412
AU Veugelers PJ; Page KA; Tindall B; Schechter MT; Moss AR; Coutinho RA;
van Griensven GJ; Municipal Health Service, Amsterdam, The Netherlands.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):318 (abstract no. PC0201). Unique
Identifier : AIDSLINE ICA10/94370197
AB OBJECTIVE: To evaluate progression from HIV seroconversion (SC) to AIDS
and death in relation to demographic, clinical and behavioral factors.
METHODS: Data of 403 homosexual men with documented dates of SC
originating from five cohorts were merged in order to study the effect
of co- and risk factors of disease progression. Cox proportional
relative hazards were estimated for factors possibly related with time
from SC to AIDS and death. RESULTS: 114 men developed AIDS and 67 died.
Median time from SC to AIDS and death was 8.4 and 8.9 years. HIV disease
progression and AIDS diagnoses patterns did not differ with regard to
geographic location. Seroconverting after 1983 was significantly related
with faster progression to AIDS and death (Relative Hazards SC to death:
< or = 1983 1; 1984 2, 1985 2.4; 1986 2.4). Older age was significantly
related with faster progression to death only (Relative Hazard 1.5 per
10 years). Use of PCP prophylaxis reduced disease progression, although
the relation with time to AIDS was not statistically significant. No
statistically significant associations were found between progression in
HIV disease and STD's, number of sexual partners, use of zidovudine,
alcohol, tobacco and recreational drugs. DISCUSSION: Our observations
suggest that later date of SC is related with faster disease
progression. Time from SC to AIDS and death in our study is shorter than
observed in other studies. These differences might be the result of the
relation between disease progression and year of seroconversion, since
the latter studies started earlier and included men with earlier dates
of SC. Relations with age and PCP prophylaxis concur with findings in
other observational studies.
DE Acquired Immunodeficiency Syndrome/MORTALITY/*PATHOLOGY Age Factors
AIDS-Related Opportunistic Infections/PREVENTION & CONTROL
*Homosexuality Human *HIV Seropositivity Male Pneumonia,
Pneumocystis carinii/PREVENTION & CONTROL Risk Factors Time Factors
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).